All Publications


X. Wang, Z. Zhao, T. Xue, Z. Tan, Z. Song, S. Wei, Y. Bo, Y. Wang, J. Cheng. "Nanoengineered polypeptides from tetraphenylethylene-functionalized N-carboxyanhydride: Synthesis, self-assembly and intrinsic aggregation-induced emission", Progress in Natural Science: Materials International 2021 31, 4, 541-54




Yang, Y., Ying, H., Li, Z., Wang, J., Ferguson, A., Zhang, Y., Cheng, J. “Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent”, Nature Communications 2021, 12, 1572.




Jiang, Y., Chen, Y., Song, Z., Tan, Z., Cheng, J. “Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation” Advanced Drug Delivery Reviews 2021, 170, 261-280.




Xia, Y., Song, Z., Tan, Z., Xue, T. Wei, S., Zhu, L., Yang, Y., Fu, H., Jiang, Y., Lin, Y., Lu, Y., Ferguson, A.L., Cheng, J. “Accelerated polymerizaton of N-carboxyanhydrides catalyzed by crown ether” Nature Communications 2021, 12, 372.




Jiang, Y., Han, M., Bo, Y., Feng, Y., Li, W., Wu, J.R., Song, Z., Zhao, Z., Tan, Z., Chen, Y., Xue, T., Fu, Z., Kuo, S.H., Lau, G.W., Lujiten, E., Cheng, J. ““Metaphilic” Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism” ACS central science. 2020, 6, 12, 2267–2276.





Song, Z., Khaw, Y. M., Pacheco, L. A., Tseng, K.-Y., Tan, Z., Cai, K., Ponnusamy, E., Cheng, J.*, Inoue, M.* “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in a multiple sclerosis animal model”, Biomater. Sci. 2020, 8, 5271.


203.  Song, Z., Chen, X., Wang, Z., King, S., Yan, H., Cai, K., Cheng, J., “Potential bleach activators with improved imide hydrolytic stability”, International Journal of Industrial Chemistry, 2020, 11, 177-185. [Link]

202.  Wang, S., Yang, Y., Ying, H., Jing, X., Wang, B., Zhang, Y., Cheng, J. “Recyclable, Self-Healable, and Highly Malleable Poly(urethane-urea)s with Improved Thermal and Mechanical Performances”, ACS Appl. Mater. Interfaces, 2020, 12, 31 35403-35414.[PDF] [SI] [Link

201.  Xue, T., Song, Z., Wang, Y., Zhu, B., Zhao, Z., Tan, Z., Wang, X., Xia, Y., Cheng, J. “Streamlined synthesis of PEG-polypeptides directly from amino acids”, Macromolecules, 2020, 53, 15, 6589-6597. [PDF] [SI] [Link]

200.  Shen, L., Cai, K., Yu, J., Cheng, J. “Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering”, ACS Omega, 2020, 5, 23, 14111-14115.[PDF] [SI] [Link]  

199.  Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574.[PDF] [SI] [Link

198.  Bo, Y., Jiang, Y., Chen, K., Cai, K., Li, W., Roy, J., Bao, Y., Cheng, J. “Targeting Infected Host Cells in vivo via Responsive Azido-Sugar Mediated Metabolic Cell Labeling Followed by Click Reaction”, Biomaterials, 2020, 238, 119843.[PDF] [SI] [Link]

197.  Song, Z., Tan, Z., Zheng, X., Fu, Z., Ponnusamy, E., Cheng, J. “Manipulating the helix-coil transition profile of synthetic polypeptides through leveraging side-chain molecular interactions”, Polym. Chem., 2020, 11, 1445-1449. [PDF] [SI] [Link]

196.  Song, Z., Fu, H., Baumgartner, R., Zhu, L., Shih, K.-C., Xia, Y., Zheng, X., Yin, L., Chipot, C., Lin, Y., Cheng, J. “Enzyme-mimetic self-catalyzed polymerization of polypeptide helices” Nature Communications, 2019, 10, 5470.[PDF] [Link

195.  Song, Z., Fu, H., Wang, J., Hui, J., Xue, T., Pacheco, L.A., Yan, H., Baumgartner, R., Wang, Z., Xia, Y., Wang, X., Yin, L., Chen. C., Roderiguez-Lopez. J., Ferguson. A., Lin. Y., Cheng. J.”Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663. [PDF] [SI] [Link]

194.  Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides“, J. Am. Chem. Soc., 2019, 141, 22, 8680-8693.[PDF] [Link]

193.  Wang, X., Song, Z., Tan, Z., Zhu, L., Xue, T., Lv, S., Fu, Z., Zheng, X., Ren, J., Cheng, J. “Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N‑Carboxyanhydrides” ACS Macro Lett., 2019, 8, 1517−1521. [PDF] [SI] [Link]

192.  Chen, X.; Zheng, G.; Cheng, J.; Yang, Y. “Supramolecular Nanotheranostics”, Theranostics, 2019, 9, 3014-3016 .[PDF] [Link]

191.  Ying, H.; Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, European Journal of Organic Chemistry, 2019, 4, 728-731.[PDF] [Link]

190.  Wang, H., Liu, Y., Xu, M., Cheng, J. “Azido-Galactose Outperforms Azido-Mannose for Metabolic Labeling and Targeting of Hepatocellular Carcinoma” Biomater. Sci., 2019, 7, 4166-4173. [PDF] [SI] [Link]

189.  Shen, L., Cai, K., Yu, J.,  Cheng, J. “Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labelling and Imaging via Cu-free Click Chemistry.”  Bioconjugate Chem, 2019, 30, 9, 2317-2322. [PDF] [SI] [Link]

188.  Wang, H., Bo, Y., Liu, Y., Xu. M., Cai. K., Wang. R., Cheng, J., “In Vivo Cancer Targeting via Glycopolyester Nanoparticle Mediated Metabolic Cell Labeling Followed by Click Reaction”  Biomaterials, 2019, 119305. [PDF] [SI] [Link]

187.  Song, Z., Tan, Z., Cheng, J., “Recent Advances and Future Perspectives of Synthetic Polypeptides from N‑Carboxyanhydrides” Macromolecules, 2019, 52, 8521-8539. [PDF] [Link]

186.  Jia, Y.; Ying, H.; Zhang, Y.; He, H.; Cheng, J. “Reconfigurable Poly (urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-shape Memory Performance”,  Macromol. Chem. Phys., 2019, 1900148.[PDF] [SI] [Link]

185.  Mei, Y., Wang, R., Jiang, W., Bo, Y., Zhang, T., Yu, J., Cheng, M., Wu, Y., Cheng, J., Ma, W.,”Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy” Biomater. Sci., 2019, 7, 2640-2651.[PDF] [Link]

184.Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide “, PNAS, 2018, 201712963. [PDF] [SI] [Link]

183. Song, Z.; Fu, H.; Wang, R.; Pacheco, L.A.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chem. Soc. Rev., 2018, 47, 7401-7425.[PDF] [Link]

182. Lv, S.; Wu, Y.; Cai, K.; He, H.; Li, Y.; Lan, M.; Chen, x.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions”, J. Am. Chem. Soc., 2018, 140, 1235–1238. [PDF] [SI] [Link]

181. Zhang, Y.; Cai, K.; Li, C.;  Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908–1915.[PDF] [SI] [Link]

180. He, H.; Chen, Y.; Li, Y.; Song, Z.; Zhong, Y.; Zhu, R.; Cheng, J.; Yin, L. “Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering”, Adv. Funct. Mater., 2018, DOI: 10.1002/adfm.201706710.[PDF] [SI] [Link]

179. He, X.; Zhang, J.; Li, C.; Zhang, Y.; Lu, Y.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Guo, X.; Sun, T.; Cheng, J.; Jiang, C. “Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy”, Theranostics, 2018, 8, 4884. [PDF] [SI

178. He, X.; Cai, K.; Zhang, Y.; Lu, Y.; Guo, Q.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Li, C.; Sun, T.; Cheng, J.; Jiang, C. “Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy”, ACS applied materials & interfaces, 2018, 10, 39455-39467. [PDF]

177. Ying, H.;  Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, Eur. J. Org. Chem., 2019, 728-731.[PDF] [SI] [Link]

176. Liu, L.; Wang, R.; Wang, C.; Wang, J.;  Chen, L.; Cheng, J. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomater. Sci., 2018,6, 997-1001. [PDF] [SI] [Link]

175. Liu, Y.; Song, Z.; Zheng, N.; Nagasaka, K.; Yin, L.; Cheng, J. “Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles”, Nanoscale, 2018, 10, 15339–15349.[PDF] [SI] [Link]

174. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomaterials Science, 2018, 6, 997-1001. [
PDF] [Link]

173. Cai, K.; Ying, H.; Cheng, J. “Dynamic Ureas with Fast and pH-independent Hydrolytic Kinetics”, Chem. Eur. J., 2018, 24, 7345 –7348. [PDF] [SI] [Link]

172. Wang, R.; Cai, K.; Wang, H.; Yin, C.;  Cheng, J. “A caged metabolic precursor for DT-diaphorase responsive cell labeling”, Chem.Comm., 2018, 54, 4878–4881.[PDF] [Link]

171. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Synthesis of indocyanine green functionalized comblike poly (aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum”, Polymer Chemistry, 2018, 9, 1206-1215. [PDF] [SI] [Link]

170. Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Albumin as a “Trojan Horse” for Polymeric Nanoconjugates Transendothelial Transport across Tumor Vasculatures for Improved Cancer Targeting”, Biomater. Sci., 2018, 6, 1189–1200. [PDF] [SI] [Link]

169. Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. [PDF] [SI] [Link]

168. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. [PDF] [SI] [Link]

167. Xiong, M.; Bao, Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song, Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”, PNAS, 2017, 114, 12675-12680.[PDF] [SI] [Link

166. Song, Z.; Mansbach, R.A.; He, H.; Shik, K.C.; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, M.P.; Ferguson, A.L.; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Commun., 2017, 8, 92.[PDF] [SI] [Link]

165. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”, Chem. Soc. Rev., 2017, 46, 6570-6599.[PDF] [Link]

164. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew. Chem. Int. Ed., 2017, 56, 10826 –10829.[PDF] [SI] [Link]

163. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106-11116.[PDF] [SI] [Link

162. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29, DOI: 10.1002/adma.201701170.[PDF] [SI] [Link]

161. Lee, M.W.; Han, M.; Bossa, G.W.; Snell, C.; Song, Z.; Tang, T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GC.L. “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871.[PDF] [SI] [Link

160. Ying, H.; Yen, J.; Wang, R.; Lai, Y.; Hu, Y.; Cheng, J. “Degradable and biocompatible hydrogels bearing a hindered urea bond”, Biomater. Sci., 2017, 5, 2398–2402.[PDF] [Link

159. Zheng, N.; Song, Z.; Yang, J.; Liu, Y.; Li, F.; Cheng, J.; Yin, L. “Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery”, Acta Biomaterialia., 2017, 58, 146–157.[PDF] [SI] [Link

158. Ren, Y.; Baumgartner, R.; Fu, H.; Schoot, P.V.D.; Cheng, J.; Lin, Y. “Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution”, Biomacromolecules, 2017, 18, 2324-2332.[PDF] [SI] [Link

157. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”,  PNAS, 2017, 114, 3993-4001.[PDF] [SI] [Link

156. Baumgartner, R.; Kuai, D.; Cheng, J. “Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers”, Biomater. Sci., 2017, 5, 1836–1844.[PDF] [SI] [Link

155. Ren, Y.; Fu, H.; Baumgartner, R.; Zhang, Y.; Cheng, J.; Lin, Y. “Folding Cooperativity of Synthetic Polypeptides with or without “Tertiary” Interactions”, ACS Macro Letter, 2017, 6, 733-737.[PDF] [SI] [Link]

154. Lv, S.; Tang, Z.; Song, W.; Zhang, D.; Li, m.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X. “Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine”, Small, 2017, 13,  1600954. DOI: 10.1002/smll.201600954.[PDF] [SI] [Link]

153. Zheng, N.; Song, Z.; Liu, Y.; Yin, L.; Cheng, J. “Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide”, Front. Chem. Sci. Eng.,  2017, 11, 521–528.[PDF] [Link

152. Tian, J.; Rodgers, Z.; Min, Y.; Wan, X.; Qiu, H.; Mi, Y.; Tian, X.; Wagner, K.T.; Caster, J.M.; Qi, Y.; Roche, K.; Zhang, T.; Cheng, J.; Wang, A.Z. “Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13, 1301-1307.[PDF] [SI] [Link]

151. Cai, K.; Wang, A.Z.; Yin, L.; Cheng, J. “Bio-Nano Interface: The Impact of Biological Environment on Nanomaterials and Their Delivery Properties”, J. Controlled Release, 2017, 263, 211-222.[PDF] [Link

150. Lv, S.; Wu, Y.; Dang, J.; Tang, Z.; Song, Z.; Ma, S.; Wang, X.; Chen, X.; Cheng, J.; Yin, L. “Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers”, Polym. Chem., 2017, 8, 1872-1877.[PDF] [SI] [Link]


86. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. “Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability”, Angew. Chem. Int. Ed., 2013, 52, 6435-6439. [PDF] [SI[Link]

85. Yin, L.; Song, Z.; Qu, Q.; Kim, K.H.; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, N.P.; Uckun, F.M.; Cheng, J. “Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation”, Angew. Chem. Int. Ed., 2013, 52, 5757-5761. [PDF] [SI[Link]

84. Yin, L.; Tang, H.; Kim, K.; Zheng, N.; Song, Z.; Gabrielson, N.P.; Lu, H.; Cheng, J. “Light‐Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery”, Angew. Chem. Int. Ed. Engl., 2013, 52, 9182–9186.  [PDF] [SI] [Link]

83. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. “Poly(iohexol) Nanoparticles As Contrast Agents for In Vivo X-ray Computed Tomography Imaging”, J. Am. Chem. Soc., 2013, 135, 13620-13623. [PDF] [SI] [Link]

82. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.V.; Cheng, J.; Lin, Y. “Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures”, J. Am. Chem. Soc., 2013, 135, 11417-11420. [PDF] [SI[Link]

81. Tang, H.; Yin, L.; Kim, K.H.; Cheng, J. “Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties”, Chem. Sci., 2013, 4, 3839-3844. [PDF] [SI] [Link]

80. Yin, L.; Song, Z.; Kim, K.H.; Zheng, N.; Gabrielson, N.P.; Cheng, J. “Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes”, Adv. Mater., 2013, 25, 3063-3070.[PDF] [SI[Link]

79. Uckun, F.M.; Qazi, S.; Cely, I.; Sahin, K.; Shahidzadeh, A.; Ozercan, I.; Yin, Q.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Yiv, S. “Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia”, Blood, 2013, 121, 4348-4354. [PDF] [Link]

78. Yin, L.; Song, Z.; Kim, K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349.

77. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, NP; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2013, 8, 78-84.

76. Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. “Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly”, Biomacromolecules, 2013, 14, 3706-3712.[PDF] [SI] [Link]

75. Zhang, Y.; Yin, Q.; Lu, H.; Xia, H.; Lin, Y.; Cheng, J. “PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation”, ACS Macro Letters, 2013, 2, 809-813. [PDF][SI[Link]

74. Xing, H.; Tang, L.; Yang, X.; Hwang, K.; Wang, W.; Yin, Q.; Wong, N.Y.; Dobrucki, L.W.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J.; Lu, Y. “Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo“, J. of Mater. Chem. B, 2013, 1, 5288-5297. [PDF[SI] [Link]

73. Tang, L.; Cheng, J. “Nonporous Silica Nanoparticles for Nanomedicine Application”, Nano Today, 2013, 8, 290-312. [PDF] [Link]

72. Yen, J.; Zhang, Y.; Gabrielson, N.P.; Yin, L.; Guan, L.; Chaudhury, I.; Lu, L.; Wang, F.; Cheng, J. “Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell”, Biomater. Sci., 2013, 1, 719-727. [PDF] [Link]

71. Yin, Q.; Tong, R.; Xu, Y.; Baek, K.; Dobrucki, L.W.; Fan, T.M.; Cheng, J. “Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug-Poly(O-Carboxyanhydride) Nanoconjugates”, Biomacromolecules, 2013, 14, 920-929. [PDF] [SI[Link]

70. Cameron, J.A.; Milner, D.J.; Lee, J.S.; Cheng, J; Fang, N.X.; Jasiuk, I.M. “Employing the biology of successful fracture repair to heal critical size bone defects”, Current Topics in Microbiology and Immunology, 2013, 367, 113-132. [PDF[Link]

69. Yin, L.; Song, Z.; Kim, H.K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349. [PDF] [SI] [Link]

69. Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Cheng, J. “Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery”, SurFACTS in Biomaterials, 2013, 18, 2. [PDF]

68. Mirshafiee, V.; Mahmoudi, M.; Lou, K.; Cheng, J.; Kraft, M.L. “Protein Corona Significantly Reduces Active Targeting Yield”, Chem.Commun., 2013, 49, 2557-2559. [PDF] [SI] [Link]

67. Tang, L.; Gabrielson, N.P.; Uckun, F.M.; Fan, T.M.; Cheng, J. “Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates”, Mol. Pharmaceutics, 2013, 10, 883-892.  [PDF] [SI] [Link]

66. Zhang, Z.; Yin, L.; Tu, C.; Song, Z.; Zhang, Y.; Xu, Y.; Tong, R.; Zhou, Q.; Ren, J.; Cheng, J. “Redox-Responsive, Core Cross-Linked Polyester Micelles”, ACS Macro Lett., 2013, 2, 40-44. [PDF[SI] [Link]

65. Zhang, Y.; Ma, L.; Deng, X.; Cheng, J. “Trigger-Responsive Chain-Shattering Polymers”, Polym. Chem., 2013, 4, 224-228. [PDF[SI] [Link]

64. Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors“, Angew. Chem. Int. Ed., 2012, 51, 12721-12726. [PDF] [SI[Link]

63. Gabrielson, N.P.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J. “Reactive and Bioactive Cationic a-Helical Polypeptide Template for Non-Viral Gene Delivery”, Angew. Chem. Int. Ed., 2012, 51, 1143-1147.[PDF] [SI] [Link]

62. Tong, R.; Cheng, J. “Zinc complex mediated regioselective O-acylation of therapeutic agents”, Chemical Science, 2012, 3, 2234-2239. [PDF] [SI[Link]

61. Gabrielson, N. P.; Lu, H.; Yin, L.; Kim, K.H.; Cheng, J. “A Cell-Penetrating Helical Polymer for siRNA Delivery to Mammalian Cells”, Molecular Therapy, 2012, 20, 1599-1609. [PDF] [Link]

60. Tong, R.; Gabrielson, N.P.; Fan, T.M.; Cheng, J. “Polymeric Nanomedicine Based on Poly(lactide) and Poly(lactic-co-glycolide)”, Current Opinion in Solid State & Materials Science, 2012, 16, 323-332. [PDF] [Link]

59. Zhang, Z.; Yin, L.; Xu, Y.; Ren, J.; Cheng, J. “Facile Functionalization of Polyesters through Thiol-yne Chemistry for the Design of Degradable, Cell‒Penetrating and Gene Delivery Dual‒Functional Agents”, Biomacromolecules, 2012, 13, 3456-3462. [PDF] [SI[Link]

58. Tang, H.; Yin, L.; Lu, H.; Cheng, J. “Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties”, Biomacromolecules, 2012, 13, 2609-2615. [PDF] [SI[Link]

57. Cely, I.; Yiv, S.;Yin, Q.; Shahidzadeh, A.; Tang, L.; Cheng, J.; Uckun, F.M. “Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles”, J. Anal. Oncol., 2012, 1, 1-9. [PDF[Link]

56. Li, L.; Yin, Q.; Cheng, J.; Lu, Y. “Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells”, Adv. Healthcare Mater., 2012, 1, 567-572. [PDF] [SI[Link]

55. Tang, L.; Azzi, J.; Kwon, M.; Mounayar, M.; Tong, R.; Yin, Q.; Moore, R.; Skartsis, N.; Fan, T.M.; Abdi, R.; Cheng, J. “Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A”, Journal of Transplantation, 2012, 896141, 1-9. [PDF] [Link]

54. Tang, L.; Fan, T.M.; Borst, L.B.; Cheng, J. “Synthesis and Biological Response of Size-Specific, Monodisperse Drug-Silica Nanoconjugates”, ACS Nano., 2012, 6, 3954-3966. [PDF] [SI] [Link]

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24. Tong, R.; Cheng, J. “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angew. Chem. Int. Ed., 2008, 47, 4830-4834. [PDF] [SI] [Link]

23. Lee, J.S.; Cheng, J.; Kim, K.Y. “Next Generation Nanosolutions for Cancer Treatment and Diagnosis”, Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF] [Link]

22. Teply, B.A.; Tong, R.; Jeong, S.Y.; Luther, G.; Sherifi, I.; Yim, C.H.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R.; Cheng, J. “The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulation the Bioavailability of Orally Delivered Macromolecules”, Biomaterials, 2008, 29, 1216-1223. [PDF] [Link]

21. Lu, H.; Cheng, J. “Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides”, J. Am. Chem. Soc., 2007, 129, 14114-14115. [PDF] [SI] [Link]

20. Tong, R.; Cheng, J. “Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF] [Link]

19. Karp, J.M.; Yeh, J.; Eng, G.; Fukuda, J.; Blumling, J.; Suh, K.Y.; Cheng, J.; Mahdavi, A.; Borenstein, J.; Langer, R.; Khademhosseini, A. “Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells”, Lab Chip, 2007, 7, 786-794. [PDF] [Link]

18. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther, G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R.S.; Farokhzad, O.C. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869-876.  [PDF][Link]

17. Farokhzad, O.C.; Cheng, J.; Teply, B.A.; Sherifi, I.; Jon, S.; Kantoff, P.W.; Richie, J.P.; Langer, R. “Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo”, PNAS, 2006, 103, 6315-6320. [PDF[Link]

16. Cheng, J.; Zeidan, R.; Mishra, M.; Liu, A.; Pun, S.H.; Kulkarni, R.P.; Jensen, G.S.; Bellocq, N.; Davis, M.E. “Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery”, J. Med. Chem., 2006, 49, 6522-6531. [PDF] [SI] [Link]

15. Schluep, T.; Hwang, J.; Cheng, J.; Heidel, J.D.; Derek, W.; Bartlett, D.W.; Davis, M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models”, Clinical Cancer Research, 2006, 12, 1606-1614. [PDF] [Link]

14. Cheng, J.; Teply, B.; Yim, C.; Jeong, S.Y.; Sherifi, I.; Jon, S.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF] [Link]

13. Fukuda, J.; Khademhosseini, A.; Yeh, J.; Eng, G.; Cheng, J.; Farokhzad, O.C.; Langer, R. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF] [Link]

12. Schluep, T.; Cheng, J.; Khin, K.T.; Davis, M.E. “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF] [Link]

11. Cheng, J.; Yin, C.H.; Teply, B.A.; Ho, D.; Farokhzad, O.C.; Langer, R.S. “Magnetite-PLGA Microparticles for Oral Delivery of Insulin”, Mater. Res. Soc. Symp. Proc., 2005, 873, 581-586. (DuPont-MIT Alliance) [PDF] [Link]

10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R.S. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells”, Analytical Chemistry, 2005, 77, 5453-5459.  [PDF] [Link]

9. Pun, S.H.; Tack, F.; Bellocq, N.C.; Cheng, J.; Grubbs, B.H.; Jensen, G.S.; Davis, M.E.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.” Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles”, Cancer biology & therapy ,2004, 3, 641-650. [PDF] [Link]

8. Cheng, J.; Khin, K.T.; Davis, M.E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF] [Link]

7. Cheng, J.; Khin, K.T.; Jensen, G.S.; Liu, A.; Davis, M.E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF] [Link]

6. Cheng, J.; Deming, T.J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, J. Am. Chem. Soc., 2001, 123, 9457-9458. [PDF] [SI] [Link]

5. Cheng, J.; Deming, T.J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF] [Link]

4. Cheng, J.; Ziller, J.W.; Deming, T.J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”, Organic Letters, 2000, 2, 1943-1946. [PDF] [SI] [Link]

3. Cheng, J.; Deming, T.J. “Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride”, Macromolecules, 1999, 32, 4745-4747. [PDF] [SI] [Link]

2. Smith, G.V.; Cheng, J.; Song, R. “New Enantioselective Heterogeneous Catalysts”, Catalysts Letters, 1997, 45, 73-78. [PDF] [Link]

1. Smith, G.V.; Cheng, J.; Song, R. “Enantioselective Hydrogenation of Prochiral C=C Bonds over Nobel Metal Catalysts Supported by β-Cyclodextrin Polymer”, Catalysts of Organic Reactions, 1996, 479-484. [PDF]