All Publications

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Song, Z.; Fu, H.; Wang, R.; Pacheco, L.A.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chem. Soc. Rev., 2018, 47, 7401-7425.[PDF] [Link]

 

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183

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Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. [PDF] [SI] [Link]

 

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168

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Kang, S.; Murphy, R.; Hwang, S.; Lee, S.; Harburg, D.; Krueger, N.; Shin, J.; Gamble, P.; Cheng, H.; Yu, S.; Liu, Z.; McCall, J.; Stephen, M.; Ying, H.; Kim, J.; Park, G.; Webb, R.; Lee, C.; Chung, S.; Wie, D.; Gujar, A.; Cheng, J.; Huang, Y.; Lee, S.; Braun, P.; Ray, W.; Rogers, J.A. ” Bioresorbable Silicon Electronic Sensors for the Brain”, Nature, 2016, 530, 71-76.

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141

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Cai, K.; He, X.; Song, Z.; Yin, Q.; Zhang, Y.; Uckun, F.M.; Jiang, C.; Cheng, J. “Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency”, J. Am. Chem. Soc., 2015, 137, 3458-3461. 

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129

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Ying, H.; Zhang, Y.; Cheng, J. “Dynamic urea bond for the design of reversible and self-healing polymers”, Nature Communications, 2014, 5, 3218.

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103

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.Tang, L.; Yang, X.; Yin, Q.; Cai, K.; Wang, H.; Chaudhury, I.; Yao, C.; Zhou, Q.; Kwon, M.; Hartman, J.A.; Dobrucki, I.T.; Dobrucki, L.W.; Borst, L.B.; Lezmi, S.; Helferich, W.G.; Ferguson, A.L.; Fan, T.M.; Cheng, J. “Investigating the optimal size of anticancer nanomedicine”, PNAS, 2014, 111, 15344-15349.

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209. X. Wang, Z. Zhao, T. Xue, Z. Tan, Z. Song, S. Wei, Y. Bo, Y. Wang, J. Cheng. "Nanoengineered polypeptides from tetraphenylethylene-functionalized N-carboxyanhydride: Synthesis, self-assembly and intrinsic aggregation-induced emission", Progress in Natural Science: Materials International 2021 31, 4, 541-54 [Link]

208. Yang, Y., Ying, H., Li, Z., Wang, J., Ferguson, A., Zhang, Y., Cheng, J. “Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent”, Nature Communications 2021, 12, 1572. [PDF] [SI] [Link]

207. Jiang, Y., Chen, Y., Song, Z., Tan, Z., Cheng, J. “Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation” Advanced Drug Delivery Reviews 2021, 170, 261-280. [PDF] [Link]

206. Xia, Y., Song, Z., Tan, Z., Xue, T. Wei, S., Zhu, L., Yang, Y., Fu, H., Jiang, Y., Lin, Y., Lu, Y., Ferguson, A.L., Cheng, J. “Accelerated polymerizaton of N-carboxyanhydrides catalyzed by crown ether” Nature Communications 2021, 12, 372. [PDF] [SI] [Link]

205. Jiang, Y., Han, M., Bo, Y., Feng, Y., Li, W., Wu, J.R., Song, Z., Zhao, Z., Tan, Z., Chen, Y., Xue, T., Fu, Z., Kuo, S.H., Lau, G.W., Lujiten, E., Cheng, J. ““Metaphilic” Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism” ACS central science. 2020, 6, 12, 2267–2276. [PDF] [SI] [Link]

204. Song, Z., Khaw, Y. M., Pacheco, L. A., Tseng, K.-Y., Tan, Z., Cai, K., Ponnusamy, E., Cheng, J.*, Inoue, M.* “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficiency in a multiple sclerosis animal model”, Biomater. Sci. 2020, 8, 5271. [PDF] [SI] [Link]
 

203.  Song, Z., Chen, X., Wang, Z., King, S., Yan, H., Cai, K., Cheng, J., “Potential bleach activators with improved imide hydrolytic stability”, International Journal of Industrial Chemistry, 2020, 11, 177-185. [Link]

202.  Wang, S., Yang, Y., Ying, H., Jing, X., Wang, B., Zhang, Y., Cheng, J. “Recyclable, Self-Healable, and Highly Malleable Poly(urethane-urea)s with Improved Thermal and Mechanical Performances”, ACS Appl. Mater. Interfaces, 2020, 12, 31 35403-35414.[PDF] [SI] [Link

201.  Xue, T., Song, Z., Wang, Y., Zhu, B., Zhao, Z., Tan, Z., Wang, X., Xia, Y., Cheng, J. “Streamlined synthesis of PEG-polypeptides directly from amino acids”, Macromolecules, 2020, 53, 15, 6589-6597. [PDF] [SI] [Link]

200.  Shen, L., Cai, K., Yu, J., Cheng, J. “Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering”, ACS Omega, 2020, 5, 23, 14111-14115.[PDF] [SI] [Link]  

199.  Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574.[PDF] [SI] [Link

198.  Bo, Y., Jiang, Y., Chen, K., Cai, K., Li, W., Roy, J., Bao, Y., Cheng, J. “Targeting Infected Host Cells in vivo via Responsive Azido-Sugar Mediated Metabolic Cell Labeling Followed by Click Reaction”, Biomaterials, 2020, 238, 119843.[PDF] [SI] [Link]

197.  Song, Z., Tan, Z., Zheng, X., Fu, Z., Ponnusamy, E., Cheng, J. “Manipulating the helix-coil transition profile of synthetic polypeptides through leveraging side-chain molecular interactions”, Polym. Chem., 2020, 11, 1445-1449. [PDF] [SI] [Link]

196.  Song, Z., Fu, H., Baumgartner, R., Zhu, L., Shih, K.-C., Xia, Y., Zheng, X., Yin, L., Chipot, C., Lin, Y., Cheng, J. “Enzyme-mimetic self-catalyzed polymerization of polypeptide helices” Nature Communications, 2019, 10, 5470.[PDF] [Link

195.  Song, Z., Fu, H., Wang, J., Hui, J., Xue, T., Pacheco, L.A., Yan, H., Baumgartner, R
., Wang, Z., Xia, Y., Wang, X., Yin, L., Chen. C., Roderiguez-Lopez. J., Ferguson. A., Lin. Y., Cheng. J.”Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663. [PDF] [SI] [Link]

194.  Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides“, J. Am. Chem. Soc., 2019, 141, 22, 8680-8693.[PDF] [Link]

193.  Wang, X., Song, Z., Tan, Z., Zhu, L., Xue, T., Lv, S., Fu, Z., Zheng, X., Ren, J., Cheng, J. “Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N‑Carboxyanhydrides” ACS Macro Lett., 2019, 8, 1517−1521. [PDF] [SI] [Link]

192.  Chen, X.; Zheng, G.; Cheng, J.; Yang, Y. “Supramolecular Nanotheranostics”, Theranostics, 2019, 9, 3014-3016 .[PDF] [Link]

191.  Ying, H.; Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, European Journal of Organic Chemistry, 2019, 4, 728-731.[PDF] [Link]

190.  Wang, H., Liu, Y., Xu, M., Cheng, J. “Azido-Galactose Outperforms Azido-Mannose for Metabolic Labeling and Targeting of Hepatocellular Carcinoma” Biomater. Sci., 2019, 7, 4166-4173. [PDF] [SI] [Link]

189.  Shen, L., Cai, K., Yu, J.,  Cheng, J. “Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labelling and Imaging via Cu-free Click Chemistry.”  Bioconjugate Chem, 2019, 30, 9, 2317-2322. [PDF] [SI] [Link]

188.  Wang, H., Bo, Y., Liu, Y., Xu. M., Cai. K., Wang. R., Cheng, J., “In Vivo Cancer Targeting via Glycopolyester Nanoparticle Mediated Metabolic Cell Labeling Followed by Click Reaction”  Biomaterials, 2019, 119305. [PDF] [SI] [Link]

187.  Song, Z., Tan, Z., Cheng, J., “Recent Advances and Future Perspectives of Synthetic Polypeptides from N‑Carboxyanhydrides” Macromolecules, 2019, 52, 8521-8539. [PDF] [Link]

186.  Jia, Y.; Ying, H.; Zhang, Y.; He, H.; Cheng, J. “Reconfigurable Poly (urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-shape Memory Performance”,  Macromol. Chem. Phys., 2019, 1900148.[PDF] [SI] [Link]

185.  Mei, Y., Wang, R., Jiang, W., Bo, Y., Zhang, T., Yu, J., Cheng, M., Wu, Y., Cheng, J., Ma, W.,”Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy” Biomater. Sci., 2019, 7, 2640-2651.[PDF] [Link]

184.Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide “, PNAS, 2018, 201712963. [PDF] [SI] [Link]

183. Song, Z.; Fu, H.; Wang, R.; Pacheco, L.A.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chem. Soc. Rev., 2018, 47, 7401-7425.[PDF] [Link]

182. Lv, S.; Wu, Y.; Cai, K.; He, H.; Li, Y.; Lan, M.; Chen, x.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions”, J. Am. Chem. Soc., 2018, 140, 1235–1238. [PDF] [SI] [Link]

181. Zhang, Y.; Cai, K.; Li, C.;  Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908–1915.[PDF] [SI] [Link]

180. He, H.; Chen, Y.; Li, Y.; Song, Z.; Zhong, Y.; Zhu, R.; Cheng, J.; Yin, L. “Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering”, Adv. Funct. Mater., 2018, DOI: 10.1002/adfm.201706710.[PDF] [SI] [Link]

179. He, X.; Zhang, J.; Li, C.; Zhang, Y.; Lu, Y.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Guo, X.; Sun, T.; Cheng, J.; Jiang, C. “Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy”, Theranostics, 2018, 8, 4884. [PDF] [SI
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178. He, X.; Cai, K.; Zhang, Y.; Lu, Y.; Guo, Q.; Zhang, Y.; Liu, L.; Ruan, C.; Chen, Q.; Chen, X.; Li, C.; Sun, T.; Cheng, J.; Jiang, C. “Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy”, ACS applied materials & interfaces, 2018, 10, 39455-39467. [PDF]

177. Ying, H.;  Yang, Y.; Cai, K.; Cheng, J. “Hindered Urea Bond: A Bilaterally Responsive Chemistry to Hydrogen Peroxide”, Eur. J. Org. Chem., 2019, 728-731.[PDF] [SI] [Link]

176. Liu, L.; Wang, R.; Wang, C.; Wang, J.;  Chen, L.; Cheng, J. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomater. Sci., 2018,6, 997-1001. [PDF] [SI] [Link]

175. Liu, Y.; Song, Z.; Zheng, N.; Nagasaka, K.; Yin, L.; Cheng, J. “Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles”, Nanoscale, 2018, 10, 15339–15349.[PDF] [SI] [Link]

174. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy”, Biomaterials Science, 2018, 6, 997-1001. [
PDF] [Link]

173. Cai, K.; Ying, H.; Cheng, J. “Dynamic Ureas with Fast and pH-independent Hydrolytic Kinetics”, Chem. Eur. J., 2018, 24, 7345 –7348. [PDF] [SI] [Link]

172. Wang, R.; Cai, K.; Wang, H.; Yin, C.;  Cheng, J. “A caged metabolic precursor for DT-diaphorase responsive cell labeling”, Chem.Comm., 2018, 54, 4878–4881.[PDF] [Link]


171. Wan, J.; Sun, L.; Wu, P.; Wang, F.; Guo, J.; Cheng, J.; Wang, C. “Synthesis of indocyanine green functionalized comblike poly (aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum”, Polymer Chemistry, 2018, 9, 1206-1215. [PDF] [SI] [Link]

170. Yin, Q.; Tang, L.; Cai, K.; Yang, X.; Yin, L.; Zhang, Y.; Dobrucki, L.W.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Albumin as a “Trojan Horse” for Polymeric Nanoconjugates Transendothelial Transport across Tumor Vasculatures for Improved Cancer Targeting”, Biomater. Sci., 2018, 6, 1189–1200. [PDF] [SI] [Link]

169. Wang, H.; Wang, R.; Cai, K.; He, H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. [PDF] [SI] [Link]

168. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622. [PDF] [SI] [Link]

167. Xiong, M.; Bao, Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song, Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”, PNAS, 2017, 114, 12675-12680.[PDF] [SI] [Link

166. Song, Z.; Mansbach, R.A.; He, H.; Shik, K.C.; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, M.P.; Ferguson, A.L.; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Commun., 2017, 8, 92.[PDF] [SI] [Link]

165. Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”, Chem. Soc. Rev., 2017, 46, 6570-6599.[PDF] [Link]

164. Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew. Chem. Int. Ed., 2017, 56, 10826 –10829.[PDF] [SI] [Link]

163. Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106-11116.[PDF] [SI] [Link

162. Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29, DOI: 10.1002/adma.201701170.[PDF] [SI] [Link]

161. Lee, M.W.; Han, M.; Bossa, G.W.; Snell, C.; Song, Z.; Tang, T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GC.L. “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871.[PDF] [SI] [Link

160. Ying, H.; Yen, J.; Wang, R.; Lai, Y.; Hu, Y.; Cheng, J. “Degradable and biocompatible hydrogels bearing a hindered urea bond”, Biomater. Sci., 2017, 5, 2398–2402.[PDF] [Link

159. Zheng, N.; Song, Z.; Yang, J.; Liu, Y.; Li, F.; Cheng, J.; Yin, L. “Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery”, Acta Biomaterialia., 2017, 58, 146–157.[PDF] [SI] [Link

158. Ren, Y.; Baumgartner, R.; Fu, H.; Schoot, P.V.D.; Cheng, J.; Lin, Y. “Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution”, Biomacromolecules, 2017, 18, 2324-2332.[PDF] [SI] [Link

157. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”,  PNAS, 2017, 114, 3993-4001.[PDF] [SI] [Link

156. Baumgartner, R.; Kuai, D.; Cheng, J. “Synthesis of controlled, high-molecular weight poly(L-glutamic acid) brush polymers”, Biomater. Sci., 2017, 5, 1836–1844.[PDF] [SI] [Link

155. Ren, Y.; Fu, H.; Baumgartner, R.; Zhang, Y.; Cheng, J.; Lin, Y. “Folding Cooperativity of Synthetic Polypeptides with or without “Tertiary” Interactions”, ACS Macro Letter, 2017, 6, 733-737.[PDF] [SI] [Link]

154. Lv, S.; Tang, Z.; Song, W.; Zhang, D.; Li, m.; Liu, H.; Cheng, J.; Zhong, W.; Chen, X. “Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine”, Small, 2017, 13,  1600954. DOI: 10.1002/smll.201600954.[PDF] [SI] [Link]

153. Zheng, N.; Song, Z.; Liu, Y.; Yin, L.; Cheng, J. “Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide”, Front. Chem. Sci. Eng.,  2017, 11, 521–528.[PDF] [Link

152. Tian, J.; Rodgers, Z.; Min, Y.; Wan, X.; Qiu, H.; Mi, Y.; Tian, X.; Wagner, K.T.; Caster, J.M.; Qi, Y.; Roche, K.; Zhang, T.; Cheng, J.; Wang, A.Z. “Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2017, 13, 1301-1307.[PDF] [SI] [Link]

151. Cai, K.; Wang, A.Z.; Yin, L.; Cheng, J. “Bio-Nano Interface: The Impact of Biological Environment on Nanomaterials and Their Delivery Properties”, J. Controlled Release, 2017, 263, 211-222.[PDF] [Link

150. Lv, S.; Wu, Y.; Dang, J.; Tang, Z.; Song, Z.; Ma, S.; Wang, X.; Chen, X.; Cheng, J.; Yin, L. “Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers”, Polym. Chem., 2017, 8, 1872-1877.[PDF] [SI] [Link]

86. Zhang, Y.; Yin, Q.; Yin, L.; Ma, L.; Tang, L.; Cheng, J. “Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability”, Angew. Chem. Int. Ed., 2013, 52, 6435-6439. [PDF] [SI[Link]

85. Yin, L.; Song, Z.; Qu, Q.; Kim, K.H.; Zheng, N.; Yao, C.; Chaudhury, I.; Tang, H.; Gabrielson, N.P.; Uckun, F.M.; Cheng, J. “Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation”, Angew. Chem. Int. Ed., 2013, 52, 5757-5761. [PDF] [SI[Link]

84. Yin, L.; Tang, H.; Kim, K.; Zheng, N.; Song, Z.; Gabrielson, N.P.; Lu, H.; Cheng, J. “Light‐Responsive Helical Polypeptides Capable of Reducing Toxicity and Unpacking DNA: Toward Nonviral Gene Delivery”, Angew. Chem. Int. Ed. Engl., 2013, 52, 9182–9186.  [PDF] [SI] [Link]

83. Yin, Q.; Yap, F.Y.; Yin, L.; Ma, L.; Zhou, Q.; Dobrucki, L.W.; Fan, T.M.; Gaba, R.C.; Cheng, J. “Poly(iohexol) Nanoparticles As Contrast Agents for In Vivo X-ray Computed Tomography Imaging”, J. Am. Chem. Soc., 2013, 135, 13620-13623. [PDF] [SI] [Link]

82. Wang, J.; Xia, H.; Zhang, Y.; Lu, H.; Kamat, R.; Dobrynin, A.V.; Cheng, J.; Lin, Y. “Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures”, J. Am. Chem. Soc., 2013, 135, 11417-11420. [PDF] [SI[Link]

81. Tang, H.; Yin, L.; Kim, K.H.; Cheng, J. “Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties”, Chem. Sci., 2013, 4, 3839-3844. [PDF] [SI] [Link]

80. Yin, L.; Song, Z.; Kim, K.H.; Zheng, N.; Gabrielson, N.P.; Cheng, J. “Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes”, Adv. Mater., 2013, 25, 3063-3070.[PDF] [SI[Link]

79. Uckun, F.M.; Qazi, S.; Cely, I.; Sahin, K.; Shahidzadeh, A.; Ozercan, I.; Yin, Q.; Gaynon, P.; Termuhlen, A.; Cheng, J.; Yiv, S. “Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia”, Blood, 2013, 121, 4348-4354. [PDF] [Link]

78. Yin, L.; Song, Z.; Kim, K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349.

77. Song, Z.; Zhang, R.; Lu, H.; Gabrielson, NP; Yin, L.; Ponnusamy, E.; Cheng, J. “Synthesis and Biomedical Applications of Polyamino Acids”, Materials Matters, 2013, 8, 78-84.

76. Wang, H.; Tang, L.; Tu, C.; Song, Z.; Yin, Q.; Yin, L.; Zhang, Z.; Cheng, J. “Redox-Responsive, Core-Cross-Linked Micelles Capable of On-Demand, Concurrent Drug Release and Structure Disassembly”, Biomacromolecules, 2013, 14, 3706-3712.[PDF] [SI] [Link]

75. Zhang, Y.; Yin, Q.; Lu, H.; Xia, H.; Lin, Y.; Cheng, J. “PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation”, ACS Macro Letters, 2013, 2, 809-813. [PDF][SI[Link]

74. Xing, H.; Tang, L.; Yang, X.; Hwang, K.; Wang, W.; Yin, Q.; Wong, N.Y.; Dobrucki, L.W.; Yasui, N.; Katzenellenbogen, J.A.; Helferich, W.G.; Cheng, J.; Lu, Y. “Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo“, J. of Mater. Chem. B, 2013, 1, 5288-5297. [PDF[SI] [Link]

73. Tang, L.; Cheng, J. “Nonporous Silica Nanoparticles for Nanomedicine Application”, Nano Today, 2013, 8, 290-312. [PDF] [Link]

72. Yen, J.; Zhang, Y.; Gabrielson, N.P.; Yin, L.; Guan, L.; Chaudhury, I.; Lu, L.; Wang, F.; Cheng, J. “Cationic, helical polypeptide-based gene delivery for IMR-90 fibroblasts and human embryonic stem cell”, Biomater. Sci., 2013, 1, 719-727. [PDF] [Link]

71. Yin, Q.; Tong, R.; Xu, Y.; Baek, K.; Dobrucki, L.W.; Fan, T.M.; Cheng, J. “Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug-Poly(O-Carboxyanhydride) Nanoconjugates”, Biomacromolecules, 2013, 14, 920-929. [PDF] [SI[Link]

70. Cameron, J.A.; Milner, D.J.; Lee, J.S.; Cheng, J; Fang, N.X.; Jasiuk, I.M. “Employing the biology of successful fracture repair to heal critical size bone defects”, Current Topics in Microbiology and Immunology, 2013, 367, 113-132. [PDF[Link]

69. Yin, L.; Song, Z.; Kim, H.K.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.P.; Cheng, J. “Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery”, Biomaterials, 2013, 34, 2340-2349. [PDF] [SI] [Link]

69. Zhang, R.; Lu, H.; Gabrielson, N.P.; Yin, L.; Cheng, J. “Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery”, SurFACTS in Biomaterials, 2013, 18, 2. [PDF]

68. Mirshafiee, V.; Mahmoudi, M.; Lou, K.; Cheng, J.; Kraft, M.L. “Protein Corona Significantly Reduces Active Targeting Yield”, Chem.Commun., 2013, 49, 2557-2559. [PDF] [SI] [Link]

67. Tang, L.; Gabrielson, N.P.; Uckun, F.M.; Fan, T.M.; Cheng, J. “Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates”, Mol. Pharmaceutics, 2013, 10, 883-892.  [PDF] [SI] [Link]

66. Zhang, Z.; Yin, L.; Tu, C.; Song, Z.; Zhang, Y.; Xu, Y.; Tong, R.; Zhou, Q.; Ren, J.; Cheng, J. “Redox-Responsive, Core Cross-Linked Polyester Micelles”, ACS Macro Lett., 2013, 2, 40-44. [PDF[SI] [Link]

65. Zhang, Y.; Ma, L.; Deng, X.; Cheng, J. “Trigger-Responsive Chain-Shattering Polymers”, Polym. Chem., 2013, 4, 224-228. [PDF[SI] [Link]

64. Tang, L.; Yang, X.; Dobrucki, L.W.; Chaudhury, I.; Yin, Q.; Yao, C.; Lezmi, S.; Helferich, W.G.; Fan, T.M.; Cheng, J. “Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugate for targeted dual-modal imaging of lymph nodes with metastatic tumors“, Angew. Chem. Int. Ed., 2012, 51, 12721-12726. [PDF] [SI[Link]

63. Gabrielson, N.P.; Lu, H.; Yin, L.; Li, D.; Wang, F.; Cheng, J. “Reactive and Bioactive Cationic a-Helical Polypeptide Template for Non-Viral Gene Delivery”, Angew. Chem. Int. Ed., 2012, 51, 1143-1147.[PDF] [SI] [Link]

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33. Tong, R.; Cheng, J. “Controlled Synthesis of Camptothecin-Polylactide Conjugates Nanoconjugates “, Bioconjugate Chem., 2010, 21, 111-121.[PDF] [Link]

32. Tong, R.; Yala, L.; Fan, T.M.; Cheng, J. “The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells”, Biomaterials, 2010, 31, 3043-3053. [PDF] [Link]

31. Lu, H.; Wang, J.; Lin, Y.; Cheng, J. “One-Pot Synthesis of Brush-Like Polymers via Integrated Ring-Opening Metathesis Polymerization and Polymerization of Amino Acid N-Carboxyanhydrides”, J. Am. Chem. Soc., 2009, 131, 13582-13583. [PDF] [SI] [Link] [Highlighted by Chemical and Engineering News]

30. Cao, Z.; Tong, R.; Xu, W.; Wong, G.W.L.; Cheng, J.; Lu, Y. “Reversible cell-specific delivery of chemotherapy drugs using aptamer-functionalized liposomes”, Angew. Chem. Int. Ed., 2009, 48, 6494-6498. [PDF] [SI] [Link]

29. Tong, R.; Cheng, J. “Ring-Opening Polymerization Mediated-Controlled Formulation of Polylactide Nanoparticles”, J. Am. Chem. Soc., 2009, 131, 4744-4754. [PDF] [SI] [Link]

28. Yigit, M.V.; Mishra, A.; Tong, R.; Cheng, J.; Wong, G.C.L.; Lu, Y. “Inorganic mercury detection and controlled release of chelating agents from ion-responsive PEG-liposomes”, Chem. Biol., 2009, 16, 937-942. [PDF] [SI] [Link]

27. Tong, R.; Tang, L.; Yala, L.; Cheng, J. “Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery”, IEEE. Eng Med Biol Soc. 2009, 1, 2400-2402.[PDF] [Link]

26. Tong, R.; Christian, D.A.; Tang, L.; Cabral, H.; Baker, J.R. Jr.; Kataoka, K.; Discher, D.; Cheng, J. “Nanopolymeric Therapeutics”, MRS Bulletin, 2009, 34, 422-431. [PDF] [Link]

25. Lu, H.; Cheng, J. “N-Trimethylsilyl Amines for Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides”, J. Am. Chem. Soc., 2008, 130, 12562–12563. [PDF][SI][Link]

24. Tong, R.; Cheng, J. “Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles”, Angew. Chem. Int. Ed., 2008, 47, 4830-4834. [PDF] [SI] [Link]

23. Lee, J.S.; Cheng, J.; Kim, K.Y. “Next Generation Nanosolutions for Cancer Treatment and Diagnosis”, Cancer and Chemotherapy Review, 2008, 3, 144-151.[PDF] [Link]

22. Teply, B.A.; Tong, R.; Jeong, S.Y.; Luther, G.; Sherifi, I.; Yim, C.H.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R.; Cheng, J. “The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulation the Bioavailability of Orally Delivered Macromolecules”, Biomaterials, 2008, 29, 1216-1223. [PDF] [Link]

21. Lu, H.; Cheng, J. “Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid-NCarboxyanhydrides”, J. Am. Chem. Soc., 2007, 129, 14114-14115. [PDF] [SI] [Link]

20. Tong, R.; Cheng, J. “Anticancer Polymeric Nanomedicines”, Polymer Reviews, 2007, 47, 345-381. [PDF] [Link]

19. Karp, J.M.; Yeh, J.; Eng, G.; Fukuda, J.; Blumling, J.; Suh, K.Y.; Cheng, J.; Mahdavi, A.; Borenstein, J.; Langer, R.; Khademhosseini, A. “Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells”, Lab Chip, 2007, 7, 786-794. [PDF] [Link]

18. Cheng, J.; Teply, B.; Sherifi, I.; Sung, J.; Luther, G.; Gu, F.X.; Levy-Nissenbaum, E.; Langer, R.S.; Farokhzad, O.C. “Formulation of Functionalized PLGA-PEG Nanoparticles for In Vivo Targeted Drug Delivery”, Biomaterials, 2007, 28, 869-876.  [PDF][Link]

17. Farokhzad, O.C.; Cheng, J.; Teply, B.A.; Sherifi, I.; Jon, S.; Kantoff, P.W.; Richie, J.P.; Langer, R. “Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo”, PNAS, 2006, 103, 6315-6320. [PDF[Link]

16. Cheng, J.; Zeidan, R.; Mishra, M.; Liu, A.; Pun, S.H.; Kulkarni, R.P.; Jensen, G.S.; Bellocq, N.; Davis, M.E. “Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Non-Viral Gene Delivery”, J. Med. Chem., 2006, 49, 6522-6531. [PDF] [SI] [Link]

15. Schluep, T.; Hwang, J.; Cheng, J.; Heidel, J.D.; Derek, W.; Bartlett, D.W.; Davis, M.E. “Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models”, Clinical Cancer Research, 2006, 12, 1606-1614. [PDF] [Link]

14. Cheng, J.; Teply, B.; Yim, C.; Jeong, S.Y.; Sherifi, I.; Jon, S.; Khademhosseini, A.; Farokhzad, O.C.; Langer, R. “Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs”, Pharmaceutical Research, 2006, 23, 557-564. [PDF] [Link]

13. Fukuda, J.; Khademhosseini, A.; Yeh, J.; Eng, G.; Cheng, J.; Farokhzad, O.C.; Langer, R. “Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components”, Biomaterials, 2006, 27,1479-86. [PDF] [Link]

12. Schluep, T.; Cheng, J.; Khin, K.T.; Davis, M.E. “Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor bearing mice”, Cancer Chemotherapy and Pharmacology, 2006, 57, 654-662. [PDF] [Link]

11. Cheng, J.; Yin, C.H.; Teply, B.A.; Ho, D.; Farokhzad, O.C.; Langer, R.S. “Magnetite-PLGA Microparticles for Oral Delivery of Insulin”, Mater. Res. Soc. Symp. Proc., 2005, 873, 581-586. (DuPont-MIT Alliance) [PDF] [Link]

10. Farokhzad, O.; Khademhosseini, A.; Jon, S.; Hermmann, A.; Cheng, J.; Chin, C.; Kiselyuk, A.; Eng, G.; Langer, R.S. “Microfluidic System for Studying the Interaction of Nanoparticles and Microparticles with Cells”, Analytical Chemistry, 2005, 77, 5453-5459.  [PDF] [Link]

9. Pun, S.H.; Tack, F.; Bellocq, N.C.; Cheng, J.; Grubbs, B.H.; Jensen, G.S.; Davis, M.E.; Brewster, M.; Janicot, M.; Janssens, B.; Floren, W.; Bakker, A.” Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles”, Cancer biology & therapy ,2004, 3, 641-650. [PDF] [Link]

8. Cheng, J.; Khin, K.T.; Davis, M.E. “Antitumor Activity of (β-Cyclodextrin Polymer-Camptothecin Conjugates”, Molecular Pharmaceutics, 2004, 1, 183-193. [PDF] [Link]

7. Cheng, J.; Khin, K.T.; Jensen, G.S.; Liu, A.; Davis, M.E. “Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin Conjugates”, Bioconjugate Chemistry, 2003, 14, 1007-1017. [PDF] [Link]

6. Cheng, J.; Deming, T.J., “Controlled Polymerization of Beta-lactams Using Metal-Amido Complexes: Synthesis of Block Copoly(β-peptides)”, J. Am. Chem. Soc., 2001, 123, 9457-9458. [PDF] [SI] [Link]

5. Cheng, J.; Deming, T.J. “Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)”, Macromolecules, 2001, 34, 5169-5174. [PDF] [Link]

4. Cheng, J.; Ziller, J.W.; Deming, T.J. “Synthesis of Optically Active β-Amino Acid N-Carboxyanhydrides”, Organic Letters, 2000, 2, 1943-1946. [PDF] [SI] [Link]

3. Cheng, J.; Deming, T.J. “Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of α-Benzyl Glutamate-N-Carboxyanhydride”, Macromolecules, 1999, 32, 4745-4747. [PDF] [SI] [Link]

2. Smith, G.V.; Cheng, J.; Song, R. “New Enantioselective Heterogeneous Catalysts”, Catalysts Letters, 1997, 45, 73-78. [PDF] [Link]

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