Gene Delivery

Polypeptides were the first set of materials considered for use as nonviral gene delivery vectors. we reported our efforts to develop a library of cationic α-helical polypeptides with CPP-like properties for gene delivery through the well-known ROP of NCAs. Our results suggest that the incorporation of α-helical cationic polypeptides into our gene delivery vector library possess the ability to disrupt endosomes and the successful application both in vitro and in vivo.