Nov. 09, 2021
A major research focus in the Cheng Research Group is to develop therapeutic nanomedicine. We are interested in several platforms and directions. Polymer-drug conjugate has been one of the major platforms for the design of drug delivery systems and the development of new therapeutics. We have worked on drug-initiated ring-opening polymerization for the synthesis of polylactide-drug conjugate and nanoconjugates. We have developed size well controlled silica-drug nanoconjugates and explored the size-distribution and size-efficacy correlation. We also developed the concept of chain-shattering polymeric therapeutics. We are interested in cancer targeting y and has developed aptamer mediated cancer targeting. We will continue working in this area and aim to develop novel chemistry for making advanced materials and systems that allow efficiency delivery of therapeutics in vitro and in vivo.